• Retinitis Pigmentosa Genetics

    October 7, 2011 | POSTED BY | Clinical Pearls

    RP can either be Autosomal Dominant, Autosomal Recessive or X-Linked. Mutations typically cluster in 3 domains of Rhodopsin. 1. The CYS110-CYS187 Bond 2. The Chromophore Binding Pocket 3. Amino Acids in the cytoplasmic tail that...

  • Know your Pharmacology

    | POSTED BY | Clinical Pearls

    Know your pharmacology including similarities between different classes of drugs. You will want to avoid using cephalosporins such as Keflex in a patient with reported allergies to penicillins. There is a well known cross allergenicity...

  • Eyelid twitching/Myokymia and Tonic Water

    September 25, 2011 | POSTED BY | Clinical Pearls

    Annoying eyelid twitches known as myokymia (not to be confused with blepharospasm) can be common in patients. Lifestyle components that contribute to myokymia are stress, fatigue, excessive use of caffeine, cigarette smoking, and constant...

  • Neovascular Glaucoma

    | POSTED BY | Clinical Pearls

    There is a balance of angiogenic and anti-angiogenic factors that control the development of new vessels throughout the body but also in the retina. In the presence of hypoxia, VEGF is up-regulated and other angiogenic factors as well....

  • Atherosclerosis vs. Arteriosclerosis vs. Arteriolosclerosis

    September 18, 2011 | POSTED BY | Clinical Pearls

    Atherosclerosis → a hardening of an artery specifically due to an atheromatous plaque Arteriosclerosis → a general term describing a hardening of medium or large arteries Arteriolosclerosis → a hardening of...